THE COMPARATIVE TOXICITY, BIOCHEMICAL AND PHYSIOLOGICAL IMPACTS OF CHLORANTRANILIPROLE AND INDOXACARB ON MAMESTRA BRASSICAE (LEPIDOPTERA: NOCTUIDAE)

The Comparative Toxicity, Biochemical and Physiological Impacts of Chlorantraniliprole and Indoxacarb on Mamestra brassicae (Lepidoptera: Noctuidae)

Background: The cabbage moth, Mamestra brassicae, is a polyphagous pest that attacks several crops.Here, the sublethal and lethal effects of chlorantraniliprole and indoxacarb were investigated on the developmental stages, detoxification enzymes, reproductive activity, calling behavior, peripheral physiology, and pheromone titer of M.brasssicae.Met

read more




Superior anti-tumor activity of the MDM2 antagonist idasanutlin and the Bcl-2 inhibitor venetoclax in p53 wild-type acute myeloid leukemia models

Abstract Background Venetoclax, a small molecule BH3 mimetic which inhibits the anti-apoptotic protein Bcl-2, and idasanutlin, a selective MDM2 antagonist, have both shown activity as single-agent treatments in pre-clinical and clinical studies in acute myeloid leukemia (AML).In this study, we deliver the rationale and molecular basis for the combi

read more